Membrane, Phase Separation, and Immune Signaling

We study how immune cells are activated to fight against pathogens and tumors. Using combined approaches of biochemical reconstitution, single molecule imaging, and cell engineering, we aim to understand how temporal and spatial organization of membrane proteins and lipids, in particular, phase separation regulates the initiation and amplification of immune cell signaling. Our work may also lead to the development of new therapeutic targets and strategies for immune diseases and cancers.

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