Publications

Orbach, R. and Su, X.
Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling.
Front Immunol. 2020 Sep 11;11:2187. doi: 10.3389/fimmu.2020.02187. Article. 

Dong, R., Libby, K.A., Blaeschke, F., Fuchs, W., Marson, A., Vale, R.D., and Su, X.
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR).
The EMBO Journal. 2020 Aug 17;39(16):e104730. doi: 10.15252/embj.2020104730. Article.

Libby, K.A., and Su, X.
Imaging Chimeric Antigen Receptor (CAR) Activation.
Methods in Molecular Biology. 2020;2111:153-160. doi: 10.1007/978-1-0716-0266-9_13. Article.

Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK.
A composition-dependent molecular clutch between T cell signaling condensates and actin.
Elife. 2019 Jul 3;8:e42695. doi: 10.7554/eLife.42695. Article.

Arellano-Santoyo H, Geyer EA, Stokasimov E, Chen GY, Su X, Hancock W, Rice LM, Pellman D.

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.

Developmental Cell. 2017 Jul 10;42(1):37-51. Article

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD.

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.

Proceedings of National Academy of Sciences U S A. 2017 Oct 31;114(44):E9338-E9345. Article

Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD.

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

Science. 2017 Mar 31;355(6332):1428-1433. Article

Comment: Costimulation, a surprising connection for immunotherapy. [Science. 2017]

Highlight: Successful checkpoint blockade requires positive co-stimulation. [Nature Reviews Immunology. 2017] 

Su X, Ditlev JA, Rosen MK, Vale RD.

Reconstitution of TCR Signaling Using Supported Lipid Bilayers.

Methods in Molecular Biology. 2017;1584:65-76. Article

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Su X*, Ditlev JA*, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK**, and Vale RD**.

Phase separation of signaling molecules promotes T cell receptor signal transduction

Science. 2016 Apr; 352(6285):595-9. (*Co-first author, **Co-corresponding author) Article

Comment: Liquidity in immune cell signaling. [Science. 2016]

Report: Building Immunity: Team Recreates a T-Cell Receptor Signaling Pathway. [Science Daily. 2016]

Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, and Pellman D.

Microtubule sliding activity of a kinesin-8 promotes spindle assembly and spindle length control.

Nature Cell Biology. 2013 Aug; 15(8): 948-57. Article

Su X, Ohi R, Pellman D.

Move in for the kill: motile microtubule regulators (Review).

Trends in Cell Biology. 2012 Nov;22(11):567-75. Article

Su X, Qiu W, Gupta ML Jr, Pereira-Leal JB, Reck-Peterson SL, Pellman D.

Mechanisms underlying the dual-mode regulation of microtubule dynamics by kip3/kinesin-8.

Molecular Cell. 2011 Sep 2;43(5):751-63. Article

Wang Q, Teng J, Shen B, Zhang W, Guo Y, Su X, Zhang C, Yu AC, Chen J.

Characterization of kinesin-like proteins in silkworm posterior silk gland cells.

Cell Research. 2010 Jun;20(6):713-27. Article