​Simon S, Bugos G, Prins R, Rajan A, Palani A, Heyer K, Stevens A, Zeng L, Thompson KA, Atilla PA, Price JP, Kluesner MG, Jaeger-Ruckstuhl CA, Shabaneh TB, Olson JM, Su X, Riddell SR.
Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy.

Nat Cancer. 2025 Mar 17. doi: 10.1038/s43018-025-00927-0. Article

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Su X.

CAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation.

Cancer Res. 2025 Mar 14;85(6):1011-1012. doi: 10.1158/0008-5472.CAN-25-0357. Article

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Boraas LC, Hu M, Martino P, Thornton L, Vejnar CE, Zhen G, Zeng L, Parker DM, Cox AL, Giraldez AJ, Su X, Mayr C, Wang S, Nicoli S.
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration.

Cell Rep. 2025 Feb 25;44(2):115237. doi: 10.1016/j.celrep.2025.115237. Article

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Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Sondek J, Su X.

Hyperactive PLCG1 drives non-canonical signaling to promote cell survival.

bioRxiv [Preprint]. 2024 Dec 18:2024.12.17.628879. doi: 10.1101/2024.12.17.628879. Article

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Xiong Y, Libby KA, Su X.
The Physical Landscape of CAR-T synapse.
Biophys J. 2024 Aug 6;123(15):2199-2210. doi: 10.1016/j.bpj.2023.09.004. Article

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Zhang X, Xiao Q, Zeng L, Hashmi F, Su X.

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.

bioRxiv [Preprint]. 2023 Oct 28:2023.10.02.560460. doi: 10.1101/2023.10.02.560460. Article

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Xiao Q, Su X.
Anti-tumor Efficacy of CD19 CAR-T in a Raji B Cell Xenografted Mouse Model.
Bio Protocol. 2023 Apr 20;13(8):e4655. doi: 10.21769/BioProtoc.4655. Article

 

Zeng L, Su X.
Biomolecular Condensation of SH2 Domain-Containing Proteins on Membranes.
Methods in Molecular Biology. 2023;2705:371-379. doi: 10.1007/978-1-0716-3393-9_20. Article

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Xiao Q, Su X.
Imaging CAR-T Synapse as a Quality Control for CAR Engineering.
Methods in Molecular Biology. 2023;2654:503-512. doi: 10.1007/978-1-0716-3135-5_33. Article

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Xiao Q, Zhang X, Tu L, Cao J, Hinrichs CS, Su X.

Size-dependent activation of CAR-T cells.

Science Immunology. 2022 Aug 5;7(74):eabl3995. doi: 10.1126/sciimmunol.abl3995. Article

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Griffith AA, Callahan KP, King NG, Xiao Q, Su X, Salomon AR.

SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR-T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells.
Journal of Proteome Research. 2022 Feb 4;21(2):395-409. doi: 10.1021/acs.jproteome.1c00735. Article

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Xiao Q, McAtee CK, Su X.

Phase separation in immune signalling.

Nature Reviews Immunology. 2022 doi: 10.1038/s41577-021-00572-5. Article

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Zeng L, Palaia I, Šarić A, Su X.

PLCγ1 promotes phase separation of T cell signaling components.

Journal of Cell Biology. 2021 Jun 7;220(6):e202009154. doi: 10.1083/jcb.202009154. Article

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Orbach R, Su, X.
Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling.
Frontiers in Immunology. 2020 Sep 11;11:2187. doi: 10.3389/fimmu.2020.02187. Article 

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Dong R, Libby KA, Blaeschke F, Fuchs W, Marson A, Vale RD, Su X.
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR).
The EMBO Journal. 2020 Aug 17;39(16):e104730. doi: 10.15252/embj.2020104730. Article

 

Libby KA, Su X.
Imaging Chimeric Antigen Receptor (CAR) Activation.
Methods in Molecular Biology. 2020;2111:153-160. doi: 10.1007/978-1-0716-0266-9_13. Article

 

Dr. Su's Publication before Yale

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Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK.
A composition-dependent molecular clutch between T cell signaling condensates and actin.
Elife. 2019 Jul 3;8:e42695. doi: 10.7554/eLife.42695. Article

 

Arellano-Santoyo H, Geyer EA, Stokasimov E, Chen GY, Su X, Hancock W, Rice LM, Pellman D.

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.

Developmental Cell. 2017 Jul 10;42(1):37-51. Article

 

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD.

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.

Proceedings of National Academy of Sciences U S A. 2017 Oct 31;114(44):E9338-E9345. Article

 

Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD.

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

Science. 2017 Mar 31;355(6332):1428-1433. Article

Comment: Costimulation, a surprising connection for immunotherapy. [Science. 2017]

Highlight: Successful checkpoint blockade requires positive co-stimulation. [Nature Reviews Immunology. 2017] 

 

Su X, Ditlev JA, Rosen MK, Vale RD.

Reconstitution of TCR Signaling Using Supported Lipid Bilayers.

Methods in Molecular Biology. 2017;1584:65-76. Article

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Su X*, Ditlev JA*, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK**, Vale RD**.

Phase separation of signaling molecules promotes T cell receptor signal transduction

Science. 2016 Apr; 352(6285):595-9. (*Co-first author, **Co-corresponding author) Article

Comment: Liquidity in immune cell signaling. [Science. 2016]

Report: Building Immunity: Team Recreates a T-Cell Receptor Signaling Pathway. [Science Daily. 2016]

 

Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, and Pellman D.

Microtubule sliding activity of a kinesin-8 promotes spindle assembly and spindle length control.

Nature Cell Biology. 2013 Aug; 15(8): 948-57. Article

 

Su X, Ohi R, Pellman D.

Move in for the kill: motile microtubule regulators (Review).

Trends in Cell Biology. 2012 Nov;22(11):567-75. Article

 

Su X, Qiu W, Gupta ML Jr, Pereira-Leal JB, Reck-Peterson SL, Pellman D.

Mechanisms underlying the dual-mode regulation of microtubule dynamics by kip3/kinesin-8.

Molecular Cell. 2011 Sep 2;43(5):751-63. Article

 

Wang Q, Teng J, Shen B, Zhang W, Guo Y, Su X, Zhang C, Yu AC, Chen J.

Characterization of kinesin-like proteins in silkworm posterior silk gland cells.

Cell Research. 2010 Jun;20(6):713-27. Article